1o7y: Difference between revisions
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[[Image:1o7y.gif|left|200px]]<br /> | [[Image:1o7y.gif|left|200px]]<br /><applet load="1o7y" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1o7y" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1o7y, resolution 3.00Å" /> | caption="1o7y, resolution 3.00Å" /> | ||
'''CRYSTAL STRUCTURE OF IP-10 M-FORM'''<br /> | '''CRYSTAL STRUCTURE OF IP-10 M-FORM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1O7Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. | 1O7Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:So4 Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7Y OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: interferon induction]] | [[Category: interferon induction]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:59:54 2007'' | ||
Revision as of 17:50, 18 December 2007
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CRYSTAL STRUCTURE OF IP-10 M-FORM
OverviewOverview
We have determined the structure of wild-type IP-10 from three crystal, forms. The crystals provide eight separate models of the IP-10 chain, all, differing substantially from a monomeric IP-10 variant examined previously, by NMR spectroscopy. In each crystal form, IP-10 chains form conventional, beta sheet dimers, which, in turn, form a distinct tetrameric assembly., The M form tetramer is reminiscent of platelet factor 4, whereas the T and, H forms feature a novel twelve-stranded beta sheet. Analytical, ultracentrifugation indicates that, in free solution, IP-10 exists in a, monomer-dimer equilibrium with a dissociation constant of 9 microM. We, propose that the tetrameric structures may represent species promoted by, the binding of glycosaminoglycans. The binding sites for several, IP-10-neutralizing mAbs have also been mapped.
About this StructureAbout this Structure
1O7Y is a Single protein structure of sequence from [1] with SO4 as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:12737818
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