3irx: Difference between revisions

Revision as of 10:35, 7 April 2010

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File:3irx.jpg

Template:STRUCTURE 3irx

Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.

Template:ABSTRACT PUBMED 19775161

About this StructureAbout this Structure

3IRX is a 2 chains structure with sequences from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J Med Chem. 2009 Oct 22;52(20):6467-73. PMID:19775161 doi:10.1021/jm901167t

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OCA

[1] Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J Med Chem. 2009 Oct 22;52(20):6467-73. PMID:19775161 doi:10.1021/jm901167t

[xtra 1]

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-'''Unreleased structure'''
+{{Seed}}
+[[Image:3irx.jpg|left|200px]]
-The entry 3irx is ON HOLD
+<!--
+The line below this paragraph, containing "STRUCTURE_3irx", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_3irx|  PDB=3irx  |  SCENE=  }}
-Authors: Ho, W.C., Arnold, E.
+===Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.===
-Description: Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate.
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:34:49 2010''
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_19775161}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 19775161 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_19775161}}
+==About this Structure==
+IRX is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_bh10 Human immunodeficiency virus type 1 bh10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRX OCA].
+==Reference==
+<ref group="xtra">PMID:19775161</ref><references group="xtra"/>
+[[Category: Human immunodeficiency virus type 1 bh10]]
+[[Category: Arnold, E.]]
+[[Category: Ho, W C.]]
+[[Category: Adam]]
+[[Category: Aid]]
+[[Category: Aspartyl protease]]
+[[Category: Cell membrane]]
+[[Category: Cytoplasm]]
+[[Category: Dna integration]]
+[[Category: Dna recombination]]
+[[Category: Dna-directed dna polymerase]]
+[[Category: Endonuclease]]
+[[Category: Hiv]]
+[[Category: Hydrolase]]
+[[Category: Lipoprotein]]
+[[Category: Membrane]]
+[[Category: Metal-binding]]
+[[Category: Multifunctional enzyme]]
+[[Category: Myristate]]
+[[Category: Nnrti]]
+[[Category: Nonnucleoside inhibitor]]
+[[Category: Nuclease]]
+[[Category: Nucleotidyltransferase]]
+[[Category: Nucleus]]
+[[Category: P51/p66]]
+[[Category: Phosphoprotein]]
+[[Category: Protease]]
+[[Category: Rna-binding]]
+[[Category: Rna-directed dna polymerase]]
+[[Category: Transferase]]
+[[Category: Transferase-hydrolase complex]]
+[[Category: Viral nucleoprotein]]
+[[Category: Virion]]
+[[Category: Zinc]]
+[[Category: Zinc-finger]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  7 10:35:11 2010''