Glycerol-3-Phosphate Dehydrogenase: Difference between revisions
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GlpD functions in the intracellular membrane of E. coli and in the inner-mitochondrial membrane of eukaryotes. In E. Coli, GlpD catalyzes and reduces the reaction of dihydroxyacetone phosphate to glycerol 3-phosphate in the [http://www.pnas.org/content/105/9/3280/F1.large.jpg glycerol metabolism pathway]. The binding of the substrate analogues (glyceraldehydes 3-phosphate, glyceric acid 2-phosphate and phosphoenolpyruvate, dihydroxyacetone phosphate)or UQ substrate analogues (2-n-heptyl-4-hydroxyquinoline N-oxide and menadione). The conformational change of the structure and resiudes of GlpD catalyzes many different metabolic reactions. | GlpD functions in the intracellular membrane of E. coli and in the inner-mitochondrial membrane of eukaryotes. In E. Coli, GlpD catalyzes and reduces the reaction of dihydroxyacetone phosphate to glycerol 3-phosphate in the [http://www.pnas.org/content/105/9/3280/F1.large.jpg glycerol metabolism pathway]. The binding of the substrate analogues (glyceraldehydes 3-phosphate, glyceric acid 2-phosphate and phosphoenolpyruvate, dihydroxyacetone phosphate)or UQ substrate analogues (2-n-heptyl-4-hydroxyquinoline N-oxide and menadione). The conformational change of the structure and resiudes of GlpD catalyzes many different metabolic reactions. | ||
===Metabolic Pathways=== | |||
====Phosphoplipid Biosynthesis==== | ====Phosphoplipid Biosynthesis==== | ||
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GlpD is also involved in the glyceroneogenesis pathway. By gluconeogenesis, phosphoenolpyruvate converts to dihydroxyacetone phosphate which is reduced by GlpD to glycerol 3-phosphate which then forms a backbone for the synthesis of triacylglycerol. | GlpD is also involved in the glyceroneogenesis pathway. By gluconeogenesis, phosphoenolpyruvate converts to dihydroxyacetone phosphate which is reduced by GlpD to glycerol 3-phosphate which then forms a backbone for the synthesis of triacylglycerol. | ||
====Respiration=== | ====Respiration==== | ||
The FAD-domain in GlpD plays a major role in the transport of electrons into the repiratory pathway. Glycerol 3-phosphate is oxidized to dihydroxyacetone phosphate with simultaneous reduction of of FAD to FADH2 occuring, and the electrons are transported to Ubiquinone, which are further transported to oxygen or nitrogen and into the respiratory pathway. | The FAD-domain in GlpD plays a major role in the transport of electrons into the repiratory pathway. Glycerol 3-phosphate is oxidized to dihydroxyacetone phosphate with simultaneous reduction of of FAD to FADH2 occuring, and the electrons are transported to Ubiquinone, which are further transported to oxygen or nitrogen and into the respiratory pathway. | ||