C-JUN: Difference between revisions

The c-Jun protein is a member of transcription factors which consist of a basic region leucine zipper region <ref name="ref1"/> <ref>PMID:8662824</ref>.  Originally identified by its homology to v-jun, the oncogene from the avian sarcomoa virus <ref name="ref4"/> Bossy-Wetzel, E., Bakiri, L., Yaniv, M.  (1997).  Induction of apoptosis by the transcription factor c-Jun.  EMO Journal.  Vol.16;7.  1695-1709 </ref>.    All these leucine zipper factors bind to DNA in one of two states: homo or heterodimers  <ref name="ref1"/>.  In conjunction with the c-Fos protein these two proteins bind to specific regions of DNA strands.  Together these two proteins form the c-fos/c-jun complex which help regulate cell growth and differentiation <ref name="ref1"/>.  the members of the jun and fos families include three Jun proteins and four Fos proteins  (c-Jun, JunB, JunD,c-Fos, Fos-B, Fra1, and Fra2) <ref name="ref3"/> PMID:12798298 </ref>.  Regulation of the complex iteslf is done by interactions between the protein and DNA in addition to the protein-protein  interactions between each of the leucine zipper domains <ref name="ref1"/>.