Collagen Structure & Function: Difference between revisions
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==Biosynthesis== | ==Biosynthesis== | ||
Collagen synthesis begins in fibroblasts <ref name="biosyn">PMID:PMC1367617</ref>. It is here that amino acids undergo activation; Proline is hydroxylated to Hydroxyproline and Lysine to Hydroxylysine. Peptide subunits of ~250 residues are assembled on the ribosome and are linked by carbohydrate residues to form α-chains <ref name="biosyn" />. Three α-chains then associate with each other and then further associate extracelluarly forming a molecule with a molecular weight of 360,000<ref name="biosyn" />. Bonds are further strengthened thus forming the insoluble collagen fibril <ref name="biosyn" />. During the process of collagen synthesis, free-hydroxyproline and hydroxylysine peptides appear as by-products, some of which are metabolized and may appear in urine <ref name="biosyn" />. | Collagen synthesis begins in fibroblasts <ref name="biosyn">PMID:PMC1367617</ref>. It is here that amino acids undergo activation; Proline is hydroxylated to Hydroxyproline and Lysine to Hydroxylysine. Peptide subunits of ~250 residues are assembled on the ribosome and are linked by carbohydrate residues to form α-chains <ref name="biosyn" />. Three α-chains then associate with each other and then further associate extracelluarly forming a molecule with a molecular weight of 360,000<ref name="biosyn" />. Bonds are further strengthened thus forming the insoluble collagen fibril <ref name="biosyn" /> <ref name="collalike" />. . During the process of collagen synthesis, free-hydroxyproline and hydroxylysine peptides appear as by-products, some of which are metabolized and may appear in urine <ref name="biosyn" />. | ||
==Molecular Structure== | ==Molecular Structure== | ||
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==Collagen-Related Disorders== | ==Collagen-Related Disorders== | ||
There are many types of disorders associated with collagen.These disorders typically occur as a result of improper folding of these molecules and occasionally due to a particular amino acid substitution | There are many types of disorders associated with collagen.These disorders typically occur as a result of improper folding of these molecules and occasionally due to a particular amino acid substitution <ref name="collalike" />. These include: | ||
*Elhers-Danlos Syndrome (IV) | *Elhers-Danlos Syndrome (IV) | ||