C-JUN: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Andrea Gorrell, Andrew Rebeyka, David Canner, Michal Harel, Alexander Berchansky

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 <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr>
-= C-JUN =
+= '''C-JUN''' =
+----
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 == Protein Function ==
-The primary function of c-Jun is in regards to DNA transcription.  Specifically, the protein is invovled in proliferation, apoptosis, oncogenic transformation and various cellular processes <ref name="ref3"/>.  for instance cells which lack an allele for c-jun show stunted growth both in vitro and in vivo <ref name="ref4"/>.  whereas a prolonged and therefore strong induction of c-jun has been in response to such things as tumor necrosis factor, stress inducing stimuli such as UV <ref name="ref4"/>.
+The primary function of c-Jun is in regards to DNA transcription.  Specifically, the protein is involved in proliferation, apoptosis, oncogenic transformation and various cellular processes <ref name="ref3"/>.  for instance cells which lack an allele for c-jun show stunted growth both in vitro and in vivo <ref name="ref4"/>.  whereas a prolonged and therefore strong induction of c-jun has been in response to such things as tumor necrosis factor, stress inducing stimuli such as UV <ref name="ref4"/>.
+== Protein Regulation ==
 == OTHER ==
+The stress-induced signalling cascade may also active c-Jun by phosphorylation.  the N-ternminal protein kinase phosphorylates Ser63 and Ser73 <ref name="ref5"/> PMID:10064599 </ref> .  Another mechanism for the activation however is interestingly through intracellular calcium concentrations.  increasing these concentrations by opening the L-type voltage gated calcium channels
+It was found that the N-terminus contains both calcium and stress-regulated transcriptional activation domains <ref name="ref5"/>.  According to the study,distinct mechanisms of c-Jun control function by calcium and stress signals <ref name="ref5"/>.