Sandbox 171: Difference between revisions

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Myosin is one of three major classes of molecular motors: myosin, dynein, and kinesin.  As the most abundant of these proteins myosin plays a structural and enzymatic role in muscle contraction and intracellular motility.  
Myosin is one of three major classes of molecular motors: myosin, dynein, and kinesin.  As the most abundant of these proteins myosin plays a structural and enzymatic role in muscle contraction and intracellular motility.  
{{STRUCTURE_2mys|  PDB=2mys| Scene =Sandbox_171/Newscene/1'>active site }}


===Structure===
===Structure===
Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. <ref name="Rayment">PMID: 8316857</ref> The molecule is asymmetric, having a long tail and two globular heads.  <ref name="Rayment" /> The heavy chains each constitute a globular head.  <ref name="Rayment" />  
Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. <ref name="Rayment">PMID: 8316857</ref> The molecule is asymmetric, having a long tail and two globular heads.  <ref name="Rayment" /> The heavy chains each constitute a globular head.  <ref name="Rayment" />  
[[Image:Myosin_head.gif]]
[[Image:Myosin_head.gif|thumb|alt=Alt text|Myosin head]]


===Function===
===Function===
{{STRUCTURE_2mys|  PDB=2mys| Scene =Sandbox_171/Newscene/1'>active site }}


===Literature Cited===
===Literature Cited===
<references/>
<references/>

Revision as of 06:36, 1 April 2010

Myosin is one of three major classes of molecular motors: myosin, dynein, and kinesin. As the most abundant of these proteins myosin plays a structural and enzymatic role in muscle contraction and intracellular motility.


Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.

PDB ID 2mys

Drag the structure with the mouse to rotate
2mys, resolution 2.80Å ()
Ligands: ,
Non-Standard Residues:
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



StructureStructure

Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. [1] The molecule is asymmetric, having a long tail and two globular heads. [1] The heavy chains each constitute a globular head. [1]

Alt text
Myosin head

FunctionFunction

Literature CitedLiterature Cited

  1. 1.0 1.1 1.2 Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM. Three-dimensional structure of myosin subfragment-1: a molecular motor. Science. 1993 Jul 2;261(5117):50-8. PMID:8316857

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Andrea Gorrell, Laurel Koopmans