Birrer Sandbox 2: Difference between revisions
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==Regulation== | ==Regulation== | ||
Substrate size is a regulator, where larger substrates inhibit alcohol dehydrogenase. Further, alcohol dehydrogenase is somewhat inhibited if the substrate is a secondary alcohol, as opposed to a primary alcohol. <ref>PMID: 4352908</ref> Pyrazoles have also been shown to be inhibitors of ADH. <ref>PMID:115004</ref> Other inhibitors include heavy metals, thiourea, purine and pyrimidine derivatives, and both chloroethanol and flouroethanol. <ref>''Alcohol Dehydrogenase'' | Substrate size is a regulator, where larger substrates inhibit alcohol dehydrogenase. Further, alcohol dehydrogenase is somewhat inhibited if the substrate is a secondary alcohol, as opposed to a primary alcohol. <ref>PMID: 4352908</ref> Pyrazoles have also been shown to be inhibitors of ADH. <ref>PMID:115004</ref> Other inhibitors include heavy metals, thiourea, purine and pyrimidine derivatives, and both chloroethanol and flouroethanol. <ref>''Alcohol Dehydrogenase''. Worthington Biochemical Corporation . 31 March 2010 < http://http://www.worthington-biochem.com/ADH/default.html></ref> Activators include sulfhydryl activating reagents, mercaptoethanol, dithiothreitol, and cysteine.<ref>''Alcohol Dehydrogenase''.Worthington Biochemical Corporation . 31 March 2010 < http://http://www.worthington-biochem.com/ADH/default.html></ref> | ||