Prolyl Endopeptidase: Difference between revisions
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Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade proline rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this therapy would be to to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine once the acidity is decreased.<ref name="Ehren2">PMID:19621078</ref> | Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade proline rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this therapy would be to to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine once the acidity is decreased.<ref name="Ehren2">PMID:19621078</ref> | ||
Research by Ehren, Govindarajan, Morón, Minshull, and Khosla has shown the ability to engineer the prolyl endopeptidase of ''Sphingomonas capsulata'' to increase the activity of this PEP under simulated gastric conditions showing the relevance of PEPs as a potential therapeutic agent for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease].<ref name="Ehren1">PMID: | Research by Ehren, Govindarajan, Morón, Minshull, and Khosla has shown the ability to engineer the prolyl endopeptidase of ''Sphingomonas capsulata'' to increase the activity of this PEP under simulated gastric conditions showing the relevance of PEPs as a potential therapeutic agent for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease].<ref name="Ehren1">PMID:18836204</ref> | ||
=== Neurological Disorders === | === Neurological Disorders === | ||