Prolyl Endopeptidase: Difference between revisions
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== Pharmaceutical Possibilities == | == Pharmaceutical Possibilities == | ||
Both human and microbial PEP have been the focus of research into their viability as therapeutic agents for several diseases. The ability of PEPs to cleave internal proline peptide bonds is of interest in the treatment of Celiac Disease which is caused by a reaction to gluten, a proline rich protein found in wheat and wheat subspecies.<ref name="Besedin"/> PEPs have also been linked to several neurological disorders due to high activity in the brain and proposed role in the degradation of neuropeptides.<ref name="Gass"/> | Both human and microbial PEP have been the focus of research into their viability as therapeutic agents for several diseases. The ability of PEPs to cleave internal proline peptide bonds is of interest in the treatment of [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease] which is caused by a reaction to gluten, a proline rich protein found in wheat and wheat subspecies.<ref name="Besedin"/> PEPs have also been linked to several neurological disorders due to high activity in the brain and a proposed role in the degradation of neuropeptides.<ref name="Gass"/> | ||
=== Celiac Disease === | === Celiac Disease === | ||