Adenylosuccinate Synthetase: Difference between revisions
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==Introduction== | ==Introduction== | ||
Adenylosuccinate Synthetase (AdSS) is part of the [http://en.wikipedia.org/wiki/Ligase Ligase] family of enzymes<ref>http://www.pdb.org/pdb/explore/explore.do?structureId=3HID</ref>. Its systematic name is IMP:L-aspartate ligase. It is mainly involved in purine bio-synthesis. It does this by catalyzing the GTP dependent changeover of IMP and aspartic acid to AMP in the presense of Mg<sup>2+</sup>.<ref>PMID:1698173 </ref> In Humans, AdSS catalyzes the first committed step in the purine nucleotide cycle by the de novo synthesis of adenosine monophosphate.<ref>PMID:649264</ref> | Adenylosuccinate Synthetase (AdSS) is part of the [http://en.wikipedia.org/wiki/Ligase Ligase] family of enzymes<ref>http://www.pdb.org/pdb/explore/explore.do?structureId=3HID</ref>. Ligase enzymes commonly 'glue' together two different molecules and create a new chemical bond. | ||
Its systematic name is IMP:L-aspartate ligase. It is mainly involved in purine bio-synthesis. It does this by catalyzing the GTP dependent changeover of IMP and aspartic acid to AMP in the presense of Mg<sup>2+</sup>.<ref>PMID:1698173 </ref> In Humans, AdSS catalyzes the first committed step in the purine nucleotide cycle by the de novo synthesis of adenosine monophosphate.<ref>PMID:649264</ref> | |||
AdSS (3hid) was isolated from [http://en.wikipedia.org/wiki/Yersinia_pestis <i>Yersinia pestis CO92</i>]and can be found in a variety of organisms ranging from yeast to bacteria to humans. Its crystal structure was determined using x-ray diffraction at a resolution of 1.60 Angstoms. The gene is located on chromosome 1 q44, in humans and is expressed in the majority of an organisms cells. | AdSS (3hid) was isolated from [http://en.wikipedia.org/wiki/Yersinia_pestis <i>Yersinia pestis CO92</i>]and can be found in a variety of organisms ranging from yeast to bacteria to humans. Its crystal structure was determined using x-ray diffraction at a resolution of 1.60 Angstoms. The gene is located on chromosome 1 q44, in humans and is expressed in the majority of an organisms cells. | ||