Prolyl Endopeptidase: Difference between revisions
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== Function == | == Function == | ||
Althought the physiological function of PEPs are not entirely understood there are several main proposed functions based on their activity and localization. | |||
PEPs are thought to have a role in the degradation of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides] due to the high concentration of PEPs in the brain and the fact that PEPs have been shown to degrade several [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides](vasopressin, β-endorphin, thyroliberin). The distribution of PEP in the brain has been found to be similar to that of certain receptors of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides] which supports PEPs being involved in the degradation of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptide] transmitters. | PEPs are thought to have a role in the degradation of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides] due to the high concentration of PEPs in the brain and the fact that PEPs have been shown to degrade several [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides](vasopressin, β-endorphin, thyroliberin). The distribution of PEP in the brain has been found to be similar to that of certain receptors of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptides] which supports PEPs being involved in the degradation of [http://en.wikipedia.org/wiki/Neuropeptides neuropeptide] transmitters. | ||
PEPs may also have a more general role in the degradation of peptides as PEP activity is found in most major organs and many peptidases cannot cleave proline residues. | |||
=== Binding Mechanism === | === Binding Mechanism === | ||