2fle: Difference between revisions

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===Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant===
===Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant===


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==About this Structure==
==About this Structure==
2FLE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLE OCA].  
2FLE is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FLE OCA].  
 
==Reference==
<ref group="xtra">PMID:18215016</ref><references group="xtra"/>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Clemente, J C.]]
[[Category: Clemente, J C.]]
Line 21: Line 30:
[[Category: Sussman, F.]]
[[Category: Sussman, F.]]
[[Category: Hiv-1 protease]]
[[Category: Hiv-1 protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Induced fit]]
[[Category: Induced fit]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Resistance]]
[[Category: Resistance]]


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Revision as of 09:24, 24 March 2010

File:2fle.png

Template:STRUCTURE 2fle

Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutantStructural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant

Template:ABSTRACT PUBMED 18215016

About this StructureAbout this Structure

2FLE is a 2 chains structure with sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. Clemente JC, Robbins A, Grana P, Paleo MR, Correa JF, Villaverde MC, Sardina FJ, Govindasamy L, Agbandje-McKenna M, McKenna R, Dunn BM, Sussman F. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation. J Med Chem. 2008 Feb 28;51(4):852-60. Epub 2008 Jan 24. PMID:18215016 doi:10.1021/jm701170f

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