Succinate Dehydrogenase: Difference between revisions

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Michael Vick, David Canner, Michal Harel, Alexander Berchansky

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 ====Ubiquinone reduction====
-Ubiquinone is initially oriented in the active site such that the O1 carbonyl group interacts with Tyr83 of SdhD via hydrogen bonding. The electrons removed during the oxidation reaction are conveyed through the iron-sulfur clusters to 3Fe-4S; <scene name='Michael_Vick_Sandbox_2/Ubq_binding_site/1'>their presence on that cluster stimulates the substrate to reorient so that a second hydrogen bond between the O4 carbonyl group and Ser27 of SdhC may form.</scene> The electrons are transferred to the substrate individually, with the addition of the first producing a radical semiquinone and the second completing the reduction to ubiquinol. This mechanism is illustrated in image 3 <ref>PMID:16950775</ref>.
+Ubiquinone is initially oriented in the active site such that the O1 carbonyl group interacts with Tyr83 of SdhD via hydrogen bonding. The electrons removed during the oxidation reaction are conveyed through the iron-sulfur clusters to 3Fe-4S; their presence on that cluster stimulates the substrate to reorient so that a second hydrogen bond between the <scene name='Michael_Vick_Sandbox_2/Ubq_binding_site/1'> O4 carbonyl group and Ser27</scene>  of SdhC may form. The electrons are transferred to the substrate individually, with the addition of the first producing a radical semiquinone and the second completing the reduction to ubiquinol. This mechanism is illustrated in image 3 <ref>PMID:16950775</ref>.
 [[Image:QuinoneMechanism.gif]]