Inositol 1,4,5-Trisphosphate Receptor: Difference between revisions
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== Function == | == Function == | ||
=== Role in Ca<sup>2+</sup> regulation === | |||
The presence of inositol 1,4,5-trisphosphate functions to increase the cytosolic concentration of Ca<sup>2+</sup>.<ref name="functionref">PMID:10378086</ref> The InsP<sub>3</sub> is formed at the plasma membrane, diffuses into the cytosol, and binds to the InsP<sub>3</sub> receptor which is found in the membrane of intracellular Ca<sup>2+</sup> stores.<ref name="functionref"/> The release of Ca<sup>2+</sup> can propagate to other cells and can help to coordinate the functionality of organ systems.<ref name="functionref"/> Areas of the body rich in the InsP<sub>3</sub> receptor are the cerebellum and, more specifically, the endoplasmic reticulum, and even the plasma membrane and nuclei of some tissues.<ref name="functionref"/> Recent results also suggest that InsP<sub>3</sub> receptors work in intrinsic Ca<sup>2+</sup> channel activity.<ref name="functionref"/> | |||
==References== | ==References== | ||