Interleukin-10: Difference between revisions
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== '''Interlukin-10''' '''[[2H24]]''' == | == '''Interlukin-10''' '''[[2H24]]''' == | ||
===Crystal structure of human IL-10=== | ===Crystal structure of human IL-10=== | ||
[[Image:2h24.png|right|150px]] | |||
Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA). | |||
RA is an autoimmune disorder that affects the synovial tissues | Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref>PMID:16982608</ref> Cytokines have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines<ref>PMID:8163935</ref>. | ||
Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA)<ref>PMID:8163935</ref>. | |||
The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual. | RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref>PMID:19758192</ref> <ref>PMID:8163935</ref>. | ||
IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. | |||
The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual<ref>PMID:19758192</ref>. | |||
When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β | |||
Make a link to the wiki website that talks about cytokines. | Make a link to the wiki website that talks about cytokines. | ||
Make a link to RA | Make a link to RA | ||
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<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
Shelly Huebert | Shelly Huebert | ||
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== '''References''' == | == '''References''' == | ||
Revision as of 04:59, 18 March 2010
Interlukin-10 2H24Interlukin-10 2H24
Crystal structure of human IL-10Crystal structure of human IL-10
Interleukin-10 is in the class cytokine.[1] Cytokines have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines[2]. Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA)[3]. RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage[4] [5]. IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual[6]. When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β Make a link to the wiki website that talks about cytokines. Make a link to RA
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Shelly Huebert
ReferencesReferences
- ↑ Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem. 2006 Nov 17;281(46):35088-96. Epub 2006 Sep 18. PMID:16982608 doi:10.1074/jbc.M606791200
- ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
- ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
- ↑ Nemec P, Goldbergova MP, Gatterova J, Vasku A, Soucek M. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. 2009 Sep;1173:501-8. PMID:19758192 doi:10.1111/j.1749-6632.2009.04625.x
- ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
- ↑ Nemec P, Goldbergova MP, Gatterova J, Vasku A, Soucek M. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. 2009 Sep;1173:501-8. PMID:19758192 doi:10.1111/j.1749-6632.2009.04625.x
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[1] Ref1
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |