Interleukin-10: Difference between revisions

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== '''Interlukin-10''' '''[[2H24]]''' ==
== '''Interlukin-10''' '''[[2H24]]''' ==
===Crystal structure of human IL-10===
===Crystal structure of human IL-10===
This is a cytokine.<ref> Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR, J Biol Chem. 2006 Nov 17;281(46):35088-96. Epub 2006 Sep 18. PMID:16982608</ref>  Cytokines function as....<ref>Reference 2</ref>
This is a cytokine.<ref>PMID:16982608</ref>  Cytokines function as....<ref>Reference 2</ref>
 
Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA).(Katsikis et al.)
RA is an autoimmune disorder that affects the synovial tissues of the affected persons, via chronic synovitis. The chronic synovitis often results in joint destruction due to re-absorption of bone and (Katsikis et al and Nemec et al) 
IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.
The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual. (Nemec)
Make a link to the wiki website that talks about cytokines.
Make a link to RA
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<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr>
<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr>
Shelly Huebert
Shelly Huebert
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Revision as of 04:09, 18 March 2010

Interlukin-10 2H24Interlukin-10 2H24

Crystal structure of human IL-10Crystal structure of human IL-10

This is a cytokine.[1] Cytokines function as....[2] Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA).(Katsikis et al.) RA is an autoimmune disorder that affects the synovial tissues of the affected persons, via chronic synovitis. The chronic synovitis often results in joint destruction due to re-absorption of bone and (Katsikis et al and Nemec et al) 

IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.

The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual. (Nemec) Make a link to the wiki website that talks about cytokines. Make a link to RA

Interleukin-10

Drag the structure with the mouse to rotate


Shelly Huebert



ReferencesReferences

  1. ↑ Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem. 2006 Nov 17;281(46):35088-96. Epub 2006 Sep 18. PMID:16982608 doi:10.1074/jbc.M606791200
  2. ↑ Reference 2

====

[1] Ref1

Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Andrea Gorrell, Shelly Huebert, David Canner, Jaime Prilusky, Michal Harel, Alexander Berchansky
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