1a1r: Difference between revisions
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[[Image:1a1r.gif|left|200px]]<br /> | [[Image:1a1r.gif|left|200px]]<br /><applet load="1a1r" size="450" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1a1r" size="450" color="white" frame="true" align="right" spinBox="true" | |||
caption="1a1r, resolution 2.5Å" /> | caption="1a1r, resolution 2.5Å" /> | ||
'''HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX'''<br /> | '''HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1A1R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. | 1A1R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Active Site, Molecule A'>AC1</scene>, <scene name='pdbsite=AC2:Active Site, Molecule B'>AC2</scene>, <scene name='pdbsite=ZN1:Zn Binding Site, Molecule A'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn Binding Site, Molecule B'>ZN2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A1R OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:06:59 2007'' | ||
Revision as of 14:57, 18 December 2007
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HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX
OverviewOverview
An estimated 1% of the global human population is infected by hepatitis C, viruses (HCVs), and there are no broadly effective treatments for the, debilitating progression of chronic hepatitis C. A serine protease located, within the HCV NS3 protein processes the viral polyprotein at four, specific sites and is considered essential for replication. Thus, it, emerges as an attractive target for drug design. We report here the 2.5, angstrom resolution X-ray crystal structure of the NS3 protease domain, complexed with a synthetic NS4A activator peptide. The protease has a, chymotrypsin-like fold and features a tetrahedrally coordinated metal ion, distal to the active site. The NS4A peptide intercalates within a beta, sheet of the enzyme core.
About this StructureAbout this Structure
1A1R is a Protein complex structure of sequences from Gb virus c with ZN as ligand. Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide., Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA, Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Gb virus c
- Protein complex
- Caron, P.R.
- Chambers, S.P.
- Dwyer, M.D.
- Fox, T.
- Harbeson, S.L.
- Kim, J.L.
- Landro, J.A.
- Lepre, C.A.
- Lin, C.
- Malley, E.T.O.
- Markland, W.
- Morgenstern, K.A.
- Murcko, M.A.
- Rice, C.M.
- Thomson, J.A.
- ZN
- Cofactor peptide
- Helicase
- Nonstructural proteins
- Serine protease
- Viral protein