Triose Phosphate Isomerase Structure & Mechanism: Difference between revisions
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Triose phosphate isomerase (TIM)<ref>PMID:16511037</ref> (PDB [[1wyi]]) is a crucial enzyme in the glycolytic pathway. <scene name='Christian_Krenk_Sandbox/Nc_rainbow/1'>TIM</scene> reversibly converts the aldose Glyceraldehyde-3-phosphate ( | Triose phosphate isomerase (TIM)<ref>PMID:16511037</ref> (PDB [[1wyi]]) is a crucial enzyme in the glycolytic pathway. <scene name='Christian_Krenk_Sandbox/Nc_rainbow/1'>TIM</scene> reversibly converts the aldose Glyceraldehyde-3-phosphate (GAP) to the ketose Dihydroxyacetone phosphate (DHAP). The interconversion proceeds by an enediol intermediate. | ||
==Structural Characteristics of TIM== | ==Structural Characteristics of TIM== | ||
The secondary structure consists of 14 alpha helices and 8 beta sheets per monomer, making it fall in the SCOP category of alpha and beta proteins. <scene name='Christian_Krenk_Sandbox/Alpha_beta_barrel/2'> | The secondary structure consists of 14 alpha helices and 8 beta sheets per monomer, making it fall in the SCOP category of alpha and beta proteins. The tertiary structure is a <scene name='Christian_Krenk_Sandbox/Alpha_beta_barrel/2'>alpha-beta barrel.</scene> | ||
The quaternary structure is a homodimer. | The quaternary structure is a homodimer. | ||