Cory Tiedeman Sandbox 1: Difference between revisions
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{{STRUCTURE_1one | PDB=1one | SCENE= }} | {{STRUCTURE_1one | PDB=1one | SCENE= }} | ||
Enolase is an enzyme that catalyzes a reaction of glycolysis. Glycolysis converts glucose into two 3-carbon molecules called pyrubate. The energy released during glycolysis is used to make ATP. | Enolase is an enzyme that catalyzes a reaction of glycolysis. Glycolysis converts glucose into two 3-carbon molecules called pyrubate. The energy released during glycolysis is used to make ATP.<ref>{{text book |author=Voet, Donald; Voet, Judith C.; Pratt, Charlotte W.|title=Fundamentals of Biochemistry: Life at the Molecular Level|edition= 3|pages=486|}}</ref> Enolase is used to convert2-phosphoglycerate (2PG) to phosphoenolpyruvate (PEP) in the 9th reaction of glycolysis.<ref>{{text book |author=Voet, Donald; Voet, Judith C.; Pratt, Charlotte W.|title=Fundamentals of Biochemistry: Life at the Molecular Level|edition= 3|pages=500|}}</ref> | ||
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As the mechanism shows, bonds then get moved around to create a different ketone and to remove an alcohol and form an alkene. Then the new molecule is released from enolase as PEP. PEP then goes on through another step in glycolysis to create pyruvate. | As the mechanism shows, bonds then get moved around to create a different ketone and to remove an alcohol and form an alkene. Then the new molecule is released from enolase as PEP. PEP then goes on through another step in glycolysis to create pyruvate. | ||
Fluoride ions inhibits glcolysis by forming a bond with Mg 2+ thus blocks the substrate (2PG) from binding to the active site of enolase. | Fluoride ions inhibits glcolysis by forming a bond with Mg 2+ thus blocks the substrate (2PG) from binding to the active site of enolase.<ref>{{text book |author=Voet, Donald; Voet, Judith C.; Pratt, Charlotte W.|title=Fundamentals of Biochemistry: Life at the Molecular Level|edition= 3|pages=500|}}</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||