Succinate Dehydrogenase: Difference between revisions
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====Succinate==== | ====Succinate==== | ||
The binding site for succinate, in which the stereospecific dehydrogenation of succinate to fumarate is catalyzed, is located entirely on SdhA. Residues Thr254, His354, and Arg399 stabilize the substrate with hydrogen bonding, while FAD removes the electrons and carries them to the first iron-sulfur cluster, 2Fe-2S, of SdhB <ref>PMID:235539</ref>. During this transfer, FAD is reduced to FADH2 <ref>ISBN:978-0-470-12930-2</ref> | The binding site for succinate, in which the stereospecific dehydrogenation of succinate to fumarate is catalyzed, is located entirely on SdhA. <scene name='Michael_Vick_Sandbox_2/Suc_bind_site_and_fad/1'>Residues Thr254, His354, and Arg399 stabilize the substrate with hydrogen bonding</scene>, while FAD removes the electrons and carries them to the first iron-sulfur cluster, 2Fe-2S, of SdhB <ref>PMID:235539</ref>. During this transfer, FAD is reduced to FADH2 <ref>ISBN:978-0-470-12930-2</ref> | ||
====Ubiquinone==== | ====Ubiquinone==== | ||