Fructose Bisphosphate Aldolase: Difference between revisions

Revision as of 04:37, 26 February 2010

Fructose biphosphate aldolase

    Fructose biphosphate aldolase is an enzyme in glycolysis.  It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP).  The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation.  Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33.   aldol cleavage produces GAP and an enamine precursor to DHAP.  Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.

Template:STRUCTURE 2ald

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Austin Drake, David Canner, Michal Harel, Alexander Berchansky, Jacob Holt

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-Fructose biphosphate aldose
+'''Fructose biphosphate aldolase'''
-This is a placeholder text to help you get started in
+     Fructose biphosphate aldolase is an enzyme in glycolysis.  It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP).  The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation.  Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33.  <scene name='Austin_Drake_Sandbox/Catalytic_site/1'>TextToBeDisplayed</scene> aldol cleavage produces GAP and an enamine precursor to DHAP.  Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.
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-Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
+{{STRUCTURE_2ald |  PDB=2ald  |  SCENE=  }}
-and display another structure.
-{{STRUCTURE_1xfb |  PDB=1xfb  |  SCENE=  }}
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Fructose Bisphosphate Aldolase: Difference between revisions

Revision as of 04:37, 26 February 2010

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