Chymotrypsin: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Karsten Theis, Alexander Berchansky, Michal Harel, Alice Harmon

@@ Line 6: / Line 6: @@
 Chymotrypsin is a protease, an enzyme catalyzing the hydrolysis of peptide bonds of proteins. Chymotrypsin helps to digest proteins in our food. Other proteases are crucial for blood clotting ([http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=stryer&part=A1378&rendertype=figure&id=A1401 thrombin and other proteases]), for the AIDS virus metabolism ([http://www.proteopedia.org/wiki/index.php/Hiv_protease HIV protease]) and for many other processes relevant to human health and agriculture.
-While chymotrypsin occurs in many organisms, the most-studied chymotrypsin is that from cows (bovine chymotrypsin). In its mature form, bovine chymotrypsin is a protein consisting of 245 amino acids. This string of amino acids folds into a <scene name='Chymotrypsin/Chymotrypsin_spacefill/2'>compact structure</scene>. (Can you guess where the substrate might bind? Try spinning around the molecule by dragging it with the mouse cursor. There should be a pocket somewhere on the surface of the enzyme). The path of the backbone is easier to see in this <scene name='Chymotrypsin/Chymotrypsin_fold_rainbow/1'>backbone cartoon</scene>, which shows that chymotrypsin folds into two large beta sheets.
+While chymotrypsin occurs in many organisms, the most-studied chymotrypsin is that from cows (bovine chymotrypsin). In its mature form, bovine chymotrypsin is a protein consisting of 245 amino acids. This string of amino acids folds into a
+<scene name='Chymotrypsin/Cpk_oriented/1'>compact structure</scene>. (Can you guess where the substrate might bind? Try spinning around the molecule by dragging it with the mouse cursor. There should be a pocket somewhere on the surface of the enzyme. Here is a <scene name='Chymotrypsin/Chymotrypsin_spacefill_active/2'>hint</scene>). The path of the backbone is easier to see in this <scene name='Chymotrypsin/Chymotrypsin_fold_rainbow/1'>backbone cartoon</scene>, which shows that chymotrypsin folds into two large beta sheets.
 ==Active site residues==