Group:SMART:2010 Pingry SMART Team: Difference between revisions

Revision as of 04:55, 11 February 2010 view source Connie Wang (talk \| contribs) 22 edits →‎'''Inherent dual cofactor use, Xylose reductase''' ← Older edit		Revision as of 05:25, 11 February 2010 view source Connie Wang (talk \| contribs) 22 edits →‎PDB ID: 1mi3, Xylose reductase with NAD+ Newer edit →
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	As with the previous protein, pink and blue highlight the alpha and beta barrel structure common to AKR's. The cofactor NAD+ is shown in wireframe and colored CPK.		As with the previous protein, pink and blue highlight the alpha and beta barrel structure common to AKR's. The cofactor NAD+ is shown in wireframe and colored CPK.

	While xylose reductase prefers to utilize NADP+, it is able to accommodate the absence of the 2'-phosphate by adapting different conformations. Asn276 shifts to Hydrogen bond		While xylose reductase prefers to utilize NADP+, it is able to accommodate the absence of the 2'-phosphate by adapting different conformations. <scene name='2010_Pingry_SMART_Team/1mi3_default/2'>Asn276</scene> shifts to Hydrogen bond with the hydroxy group of the NAD+ in place of the phosphate group.