1dan: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
1DAN is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with BGC, FUC, CA, CAC, CL and CH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1DAN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb75_1.html Tissue Factor]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?1DAN OCA]]. | 1DAN is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with BGC, FUC, CA, CAC, CL and CH2 as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1DAN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb75_1.html Tissue Factor]]. Full crystallographic information is available from | ||
[[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DAN OCA]]. | |||
==Reference== | ==Reference== | ||
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[[Category: FUC]] | [[Category: FUC]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 18: | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 18:03:26 2007'' | ||
Revision as of 18:58, 28 October 2007
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OverviewOverview
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
About this StructureAbout this Structure
1DAN is a [Protein complex] structure of sequences from [Homo sapiens] with BGC, FUC, CA, CAC, CL and CH2 as [ligands]. The following page contains interesting information on the relation of 1DAN with [Tissue Factor]. Full crystallographic information is available from
[OCA].
ReferenceReference
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor., Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D, Nature. 1996 Mar 7;380(6569):41-6. PMID:8598903
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