1hkk: Difference between revisions
New page: left|200px<br /> <applet load="1hkk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hkk, resolution 1.85Å" /> '''HIGH RESOULTION CRY... |
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==About this Structure== | ==About this Structure== | ||
1HKK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and AMI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKK OCA]]. | 1HKK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and AMI as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKK OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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Revision as of 09:42, 30 October 2007
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HIGH RESOULTION CRYSTAL STRUCTURE OF HUMAN CHITINASE IN COMPLEX WITH ALLOSAMIDIN
OverviewOverview
The pseudotrisaccharide allosamidin is a potent family 18 chitinase, inhibitor with demonstrated biological activity against insects, fungi, and the Plasmodium falciparum life cycle. The synthesis and biological, properties of several derivatives have been reported. The structural, interactions of allosamidin with several family 18 chitinases have been, determined by x-ray crystallography previously. Here, a high resolution, structure of chitotriosidase, the human macrophage chitinase, in complex, with allosamidin is presented. In addition, complexes of the allosamidin, derivatives demethylallosamidin, methylallosamidin, and glucoallosamidin B, are described, together with their inhibitory properties. Similar to other, chitinases, inhibition of the human chitinase by allosamidin ... [(full description)]
About this StructureAbout this Structure
1HKK is a [Single protein] structure of sequence from [Homo sapiens] with ZN and AMI as [ligands]. Active as [Hydrolase], with EC number [3.2.1.14]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of allosamidin derivatives in complex with human macrophage chitinase., Rao FV, Houston DR, Boot RG, Aerts JM, Sakuda S, van Aalten DM, J Biol Chem. 2003 May 30;278(22):20110-6. Epub 2003 Mar 14. PMID:12639956
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