1hk2: Difference between revisions
New page: left|200px<br /> <applet load="1hk2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hk2, resolution 2.80Å" /> '''HUMAN SERUM ALBUMIN... |
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==About this Structure== | ==About this Structure== | ||
1HK2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T44 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HK2 OCA]]. | 1HK2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with T44 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HK2 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: thyroxine]] | [[Category: thyroxine]] | ||
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Revision as of 09:41, 30 October 2007
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HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE)
OverviewOverview
Human serum albumin (HSA) is the major protein component of blood plasma, and serves as a transporter for thyroxine and other hydrophobic compounds, such as fatty acids and bilirubin. We report here a structural, characterization of HSA-thyroxine interactions. Using crystallographic, analyses we have identified four binding sites for thyroxine on HSA, distributed in subdomains IIA, IIIA, and IIIB. Mutation of residue R218, within subdomain IIA greatly enhances the affinity for thyroxine and, causes the elevated serum thyroxine levels associated with familial, dysalbuminemic hyperthyroxinemia (FDH). Structural analysis of two FDH, mutants of HSA (R218H and R218P) shows that this effect arises because, substitution of R218, which contacts the hormone bound in subdomain IIA, produces ... [(full description)]
About this StructureAbout this Structure
1HK2 is a [Single protein] structure of sequence from [Homo sapiens] with T44 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia., Petitpas I, Petersen CE, Ha CE, Bhattacharya AA, Zunszain PA, Ghuman J, Bhagavan NV, Curry S, Proc Natl Acad Sci U S A. 2003 May 27;100(11):6440-5. Epub 2003 May 12. PMID:12743361
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