3io7: Difference between revisions

Revision as of 23:30, 11 November 2009

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3io7.jpg

Template:STRUCTURE 3io7

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK22-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Template:ABSTRACT PUBMED 19857967

DiseaseDisease

Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]

About this StructureAbout this Structure

3IO7 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Ledeboer MW, Pierce AC, Duffy JP, Gao H, Messersmith D, Salituro FG, Nanthakumar S, Come J, Zuccola HJ, Swenson L, Shlyakter D, Mahajan S, Hoock T, Fan B, Tsai WJ, Kolaczkowski E, Carrier S, Hogan JK, Zessis R, Pazhanisamy S, Bennani YL. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6529-33. Epub 2009 Oct 24. PMID:19857967 doi:10.1016/j.bmcl.2009.10.053

Page seeded by OCA on Wed Nov 11 22:30:26 2009

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OCA

[1] Ledeboer MW, Pierce AC, Duffy JP, Gao H, Messersmith D, Salituro FG, Nanthakumar S, Come J, Zuccola HJ, Swenson L, Shlyakter D, Mahajan S, Hoock T, Fan B, Tsai WJ, Kolaczkowski E, Carrier S, Hogan JK, Zessis R, Pazhanisamy S, Bennani YL. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6529-33. Epub 2009 Oct 24. PMID:19857967 doi:10.1016/j.bmcl.2009.10.053

[xtra 1]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{Seed}}
+[[Image:3io7.jpg|left|200px]]
-The entry 3io7 is ON HOLD  until Paper Publication
+<!--
+The line below this paragraph, containing "STRUCTURE_3io7", creates the "Structure Box" on the page.
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+or leave the SCENE parameter empty for the default display.
+-->
+{{STRUCTURE_3io7|  PDB=3io7  |  SCENE=  }}
-Authors: Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
+===2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2===
-Description: 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:43:48 2009''
+<!--
+The line below this paragraph, {{ABSTRACT_PUBMED_19857967}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 19857967 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_19857967}}
+==Disease==
+Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]]
+==About this Structure==
+IO7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IO7 OCA].
+==Reference==
+<ref group="xtra">PMID:19857967</ref><references group="xtra"/>
+[[Category: Homo sapiens]]
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Ledeboer, M W.]]
+[[Category: Pierce, A C.]]
+[[Category: Zuccola, H J.]]
+[[Category: Atp-binding]]
+[[Category: Chromosomal rearrangement]]
+[[Category: Disease mutation]]
+[[Category: Inhibitor]]
+[[Category: Jak2]]
+[[Category: Janus kinase]]
+[[Category: Kinase]]
+[[Category: Membrane]]
+[[Category: Nucleotide-binding]]
+[[Category: Phosphoprotein]]
+[[Category: Polymorphism]]
+[[Category: Proto-oncogene]]
+[[Category: Sh2 domain]]
+[[Category: Transferase]]
+[[Category: Tyrosine-protein kinase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:30:26 2009''

3io7: Difference between revisions

Revision as of 23:30, 11 November 2009

Contents

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK22-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

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About this StructureAbout this Structure

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3io7: Difference between revisions

Revision as of 23:30, 11 November 2009

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK22-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

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