Theoretical models: Difference between revisions
Eric Martz (talk | contribs) →Empirical Models: adding content |
Eric Martz (talk | contribs) →Homology Models: adding content |
||
| Line 11: | Line 11: | ||
==Homology Models== | ==Homology Models== | ||
''Homology models'', also called ''comparative models'', are obtained by folding a target protein sequence to fit an empirically-determined template model. The registration between residues in the target and template is determined by an amino acid sequence alignment. Errors or uncertainties in the sequence alignment result in errors or uncertainties in the homology model. Provided there is sufficient sequence identity between the target and template, the main chain in homology models is usually mostly correct. However, the positions of sidechains in homology models are usually incorrect. | ''Homology models'', also called ''comparative models'', are obtained by folding a target protein sequence to fit an empirically-determined template model. The registration between residues in the target and template is determined by an amino acid sequence alignment between the target and template sequences. Errors or uncertainties in the sequence alignment result in errors or uncertainties in the homology model. Provided there is sufficient sequence identity between the target and template, the main chain in homology models is usually mostly correct. However, the positions of sidechains in homology models are usually incorrect. | ||
Empirically-determined templates with adequate sequence identity are available for less than half of all protein sequences. One of the major goals of [[structural genomics]] is to increase the sequence diversity of the available empirically-determined structures that can be used as templates for homology modeling. | Empirically-determined templates with adequate sequence identity are available for less than half of all protein sequences. One of the major goals of [[structural genomics]] is to increase the sequence diversity of the available empirically-determined structures that can be used as templates for homology modeling. | ||