2c7n: Difference between revisions
New page: left|200px<br /> <applet load="2c7n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c7n, resolution 2.10Å" /> '''HUMAN RABEX-5 RESID... |
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==About this Structure== | ==About this Structure== | ||
2C7N is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C7N OCA]]. | 2C7N is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C7N OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:44:15 2007'' | ||
Revision as of 09:39, 30 October 2007
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HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN
OverviewOverview
The interaction between ubiquitinated proteins and intracellular proteins, harboring ubiquitin binding domains (UBDs) is critical to a multitude of, cellular processes. Here, we report that Rabex-5, a guanine nucleotide, exchange factor for Rab5, binds to Ub through two independent UBDs. These, UBDs determine a number of properties of Rabex-5, including its coupled, monoubiquitination and interaction in vivo with ubiquitinated EGFRs., Structural and biochemical characterization of the UBDs of Rabex-5, revealed that one of them (MIU, motif interacting with ubiquitin) binds to, Ub with modes superimposable to those of the UIM (ubiquitin-interacting, motif):Ub interaction, although in the opposite orientation. The other, UBD, RUZ (Rabex-5 ubiquitin binding zinc finger) binds to a surface of ... [(full description)]
About this StructureAbout this Structure
2C7N is a [Protein complex] structure of sequences from [Homo sapiens] with ZN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin., Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR, Cell. 2006 Mar 24;124(6):1183-95. Epub 2006 Feb 23. PMID:16499958
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