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Michael Purol Sandbox 1: Difference between revisions

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{{STRUCTURE_1bd8 | PDB= 1bd8 |  SCENE=  }}
{{STRUCTURE_1bd8 | PDB= 1bd8 |  SCENE=  }}


==Overview of p19==
==p19 in the Cell Cycle==


CDK Inhibitor p19INK4d is a Cyclin-Dependent Kinase (CDK) Inhibitor in the INK4 family of CDK inhibitors.  The INK4 CDK inhibitors bind and inhibit CDK4 and CDK6, the two cyclin-dependent kinases involved in the progression through the G1 phase of the cell cycle.
CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors.  Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6.  These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase.
 
 


<scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene>
<scene name='Michael_Purol_Sandbox_1/Lys_62/1'>Lys 62</scene>

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michael Purol, Ann Taylor, David Canner
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