Kwon sandbox: Difference between revisions
Jason Kwon (talk | contribs) No edit summary |
Jason Kwon (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
== | == Introduction == | ||
---- | ---- | ||
| Line 12: | Line 12: | ||
== | ==Relevance to Cancer== | ||
In 1911 a virologist named Peyton Rous saw that sarcoma in chickens could be transmitted through cell free extracts from the sarcoma tumors. This suggested that a virus was possibly the etiologic agent of the sarcoma. To see if it was true scientists studied an avian retrovirus which was found to induce myeloid leukemia, sarcomas, liver, kidney, and other tumors. They also found a gene in the body named V-myc. V-myc (myelocytomatosis viral oncogene homolog 1) is the gene in the body that aided the virus in causing cancer in the chickens. Soon after they found genes in humans with Burkitt's Lyphoma that had a similar makeup to the V-myc gene. Later they found that C-myc like V-myc causes cancer when the gene is changed or affected by something else. | In 1911 a virologist named Peyton Rous saw that sarcoma in chickens could be transmitted through cell free extracts from the sarcoma tumors. This suggested that a virus was possibly the etiologic agent of the sarcoma. To see if it was true scientists studied an avian retrovirus which was found to induce myeloid leukemia, sarcomas, liver, kidney, and other tumors. They also found a gene in the body named V-myc. V-myc (myelocytomatosis viral oncogene homolog 1) is the gene in the body that aided the virus in causing cancer in the chickens. Soon after they found genes in humans with Burkitt's Lyphoma that had a similar makeup to the V-myc gene. Later they found that C-myc like V-myc causes cancer when the gene is changed or affected by something else. | ||
== | ==Research in Structure and Function== | ||
The c-myc protein cannot homodimerize without the protein Max. Max can sometimes heterodimerize with Mad family proteins. The Mad-Max, Mad3-Max, Mad4-Max, and Mnt-Max heterodimers are antagonist of c-myc. The myc-max connection is unstable which allows for high populations of dissociated monomers and it impedes reassortment dictated by the level of expression of c-myc, mad, and mxi1 genes and transduction of cell growth and differentiation signals. For oncogenic activity to occur c-myc must bind with the Max protein. All max proteins will bind to the same DNA sequence. | The c-myc protein cannot homodimerize without the protein Max. Max can sometimes heterodimerize with Mad family proteins. The Mad-Max, Mad3-Max, Mad4-Max, and Mnt-Max heterodimers are antagonist of c-myc. The myc-max connection is unstable which allows for high populations of dissociated monomers and it impedes reassortment dictated by the level of expression of c-myc, mad, and mxi1 genes and transduction of cell growth and differentiation signals. For oncogenic activity to occur c-myc must bind with the Max protein. All max proteins will bind to the same DNA sequence. | ||