Intrinsically Disordered Protein: Difference between revisions
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IUPs play roles in processes such as: | IUPs play roles in processes such as: | ||
Cell signaling and cell cycle regulation, e.g. cyclin dependent kinase inhibitor p21Waf1/Cip1/Sdi1<ref>PMID: 8876165</ref> | * Cell signaling and cell cycle regulation, e.g. cyclin dependent kinase inhibitor p21Waf1/Cip1/Sdi1<ref>PMID: 8876165</ref> | ||
Oncogene, e.g. P53 contains large unstructured regions in its native state<ref>PMID: 12367518</ref> | * Oncogene, e.g. P53 contains large unstructured regions in its native state<ref>PMID: 12367518</ref> | ||
Assembly of cytoskeletal proteins, e.g. Tau protein<ref>PMID: 7929085</ref> | * Assembly of cytoskeletal proteins, e.g. Tau protein<ref>PMID: 7929085</ref> | ||
Membrane fusion and membrane transport, e.g. isolated components of the SNARE complex<ref>PMID: 10048921</ref> | * Membrane fusion and membrane transport, e.g. isolated components of the SNARE complex<ref>PMID: 10048921</ref> | ||
DNA recognition molecules, e.g. the basic DNA-binding region of the leucine zipper protein, GCN4<ref>PMID: 2145515</ref> | * DNA recognition molecules, e.g. the basic DNA-binding region of the leucine zipper protein, GCN4<ref>PMID: 2145515</ref> | ||
Protein-RNA recognition, e.g. ribosomal proteins L11-C76<ref>PMID: 8989327</ref> | * Protein-RNA recognition, e.g. ribosomal proteins L11-C76<ref>PMID: 8989327</ref> | ||
Transcriptional activation domains, e.g. NF-kb<ref>PMID: 7929265</ref>, Glucocorticoid receptor, 77-262 fragment <ref>PMID: 10196139</ref> | * Transcriptional activation domains, e.g. NF-kb<ref>PMID: 7929265</ref>, Glucocorticoid receptor, 77-262 fragment <ref>PMID: 10196139</ref> | ||
Amyloid formation, e.g. prion protein, N terminal part<ref>PMID: 9391046</ref>, NACP precursor of the non-Ab component of the amyloid plaque<ref>PMID: 8901511</ref> | * Amyloid formation, e.g. prion protein, N terminal part<ref>PMID: 9391046</ref>, NACP precursor of the non-Ab component of the amyloid plaque<ref>PMID: 8901511</ref> | ||
== Protein disorder predictors == | == Protein disorder predictors == | ||