1dyw: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
1DYW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]]. Active as [[http://en.wikipedia.org/wiki/ | 1DYW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]]. Active as [[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]]. Structure known Active Site: CBS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DYW OCA]]. | ||
==Reference== | ==Reference== | ||
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans., Dornan J, Page AP, Taylor P, Wu S, Winter AD, Husi H, Walkinshaw MD, J Biol Chem. 1999 Dec 3;274(49):34877-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10574961 10574961] | Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans., Dornan J, Page AP, Taylor P, Wu S, Winter AD, Husi H, Walkinshaw MD, J Biol Chem. 1999 Dec 3;274(49):34877-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10574961 10574961] | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Peptidylprolyl isomerase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dornan, J.]] | [[Category: Dornan, J.]] | ||
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[[Category: rotamase]] | [[Category: rotamase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:33:07 2007'' | ||
Revision as of 11:28, 30 October 2007
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BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF A DIVERGENT LOOP CYCLOPHILIN FROM CAENORHABDITIS ELEGANS
OverviewOverview
Cyclophilin 3 (CYP-3) is one of the most abundantly expressed cyclophilin, isoforms in the free living nematode Caenorhabditis elegans. The detailed, post-embryonic expression pattern of the cyp-3 transcript is unusual, peaking during early larval development. The spatial expression pattern, was examined via reporter gene analysis demonstrating that the cyp-3, transcript is exclusively expressed in the single anterior excretory cell., Recombinant cyclophilin 3 has been purified, crystallized and solved to a, resolution of 1.8 A. The peptidyl-prolyl isomerase activity of CYP-3 has, been characterized against the substrate, N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide, and gives a k(cat)/K(m) value, of 2.4 x 10(6) M(-1) s(-1). The immunosuppressive drug cyclosporin A binds, and inhibits CYP-3 ... [(full description)]
About this StructureAbout this Structure
1DYW is a [Single protein] structure of sequence from [Caenorhabditis elegans]. Active as [Peptidylprolyl isomerase], with EC number [5.2.1.8]. Structure known Active Site: CBS. Full crystallographic information is available from [OCA].
ReferenceReference
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans., Dornan J, Page AP, Taylor P, Wu S, Winter AD, Husi H, Walkinshaw MD, J Biol Chem. 1999 Dec 3;274(49):34877-83. PMID:10574961
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