Z-DNA: Difference between revisions
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=== DLM-1 === | === DLM-1 === | ||
DLM-1 is also known as Z-DNA binding protein 1 (ZBP1). It is expressed by a tumor associated gene in lymphatic tissues | DLM-1 is also known as Z-DNA binding protein 1 (ZBP1). It is expressed by a tumor associated gene in lymphatic tissues of mice with mouse ovarian ascites tumor.<ref name ='Wang'>PMID:17485386</ref> DLM-1 has two Z-DNA binding domains analogous to the Z-alpha and Z- beta domains in ADAR1. Comparison of Z-DNA binding of DLM-1 and ADAR1 revealed a common structure recognition core within the binding domain. However the role of DLM-1 binding to Z-DNA in tumor development is not known. | ||
Z-DNA binding proteins have common structural characteristics. The binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above, disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref> | Z-DNA binding proteins have common structural characteristics. The binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above, disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref> | ||