Z-DNA: Difference between revisions
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[[Image:Hbonding_Z-DNA.png|left|thumb|400px|Polar Interactions between ADAR1 and Z-DNA]] | [[Image:Hbonding_Z-DNA.png|left|thumb|400px|Polar Interactions between ADAR1 and Z-DNA]] | ||
The double stranded RNA substrate for ADAR1 is formed by folding of 3' intron back onto the exon containing the site to be edited. This shows that the editing of RNA occurs before the splicing of RNA providing an explanation for the binding of Z-DNA by ADAR1. Z-DNA may localize the editing activity of ADAR1 to a particular region within a gene, thus preventing indiscriminate modification. This allows for editing of the nascent transcript and | The double stranded RNA substrate for ADAR1 is formed by folding of 3' intron back onto the exon containing the site to be edited. This shows that the editing of RNA occurs before the splicing of RNA providing an explanation for the binding of Z-DNA by ADAR1. Z-DNA may localize the editing activity of ADAR1 to a particular region within a gene, thus preventing indiscriminate modification. This allows for editing of the nascent transcript and blocks further transcription of gene. It has also been suggested that the extent of adenosine to inosine is proportional to amount of Z-DNA and also the ease with which the surrounding sequences adopt Z-DNA conformation. According to a study binding of ADAR1 to Z-DNA resulted in the increase in promoter activity of the gene which suggests that Z-DNA formation in the promoter region is itself involved in the regulation of transcription.<ref name = 'Rich'>PMID:12838348</ref> | ||
=== Vaccinia virus E3L protein === | === Vaccinia virus E3L protein === | ||