Influenza hemagglutinin: Difference between revisions
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[[Image:HA sfp model.jpg|left|thumb|A physical model based on [[5hmg]] from the [http://cbm.msoe.edu/ MSOE Center for BioMolecular Modeling]]Influenza Hemagglutinin is one of two proteins found on the surface of an influenza virus. Hemagglutinin plays a key role in both host cell recognition and membrane fusion. | |||
===Structure=== | ===Structure=== | ||
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The hemagglutinin protein is initially assembled into a homo-trimer. Each of the three identical proteins consists of 549 amino acids. Later during the maturation of the virus, the monomers are cleaved by a protease to generate two chains known as HA1 and HA2. | The hemagglutinin protein is initially assembled into a homo-trimer. Each of the three identical proteins consists of 549 amino acids. Later during the maturation of the virus, the monomers are cleaved by a protease to generate two chains known as HA1 and HA2. | ||
<applet load="5HMG" size="300" color="white" frame="true" align="right" caption="Influenza Hemagglutinin | <applet load="5HMG" size="300" color="white" frame="true" align="right" caption="Influenza Hemagglutinin based on [[5hmg]]" /> | ||
====HA1==== | ====HA1==== | ||
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~We hope to have a short video available soon that will display a physical model of this protein and some of the concepts discussed above. | ~We hope to have a short video available soon that will display a physical model of this protein and some of the concepts discussed above. | ||
==<font color = 'red'>MSOE Center for BioMolecular Modeling</font>== | ==External Links== | ||
===<font color = 'red'>MSOE Center for BioMolecular Modeling</font>=== | |||
[[Image:Center for BioMolecular Modeling Logo.jpg|left|200px]] | [[Image:Center for BioMolecular Modeling Logo.jpg|left|200px]] | ||
The physical models shown on this page were designed and built by the MSOE Center for BioMolecular Modeling. For more information about physical protein modeling, visit the CBM web site at [http://cbm.msoe.edu/ http://cbm.msoe.edu/] . | The physical models shown on this page were designed and built by the MSOE Center for BioMolecular Modeling. For more information about physical protein modeling, visit the CBM web site at [http://cbm.msoe.edu/ http://cbm.msoe.edu/] . | ||