Sandbox Z-DNA: Difference between revisions

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 == Structure ==
-Z-DNA can form ''invitro'' from B-DNA by raising negative super helical stress or under physiological salt conditions when deoxycytosine is 5-methylated. The formation of Z-DNA which requires energy is an active process ''invivo''. A mechanism for initiation of Z-DNA involves formation of negative supercoils behind a moving  RNA polymerase when it moves through DNA double helix. <ref name = 'Rich'>PMID:12838348</ref><ref name ='Wang'>PMID:17485386</ref> `
+Z-DNA can form ''invitro'' from B-DNA by raising negative super helical stress or under low salt conditions when deoxycytosine is 5-methylated. The formation of Z-DNA ''invivo'' is an energy requiring process. Z-DNA forms behind a moving  RNA polymerase when it moves through DNA double helix during transcription and is subsequently stabilized due to the generation of negative supercoils. <ref name = 'Rich'>PMID:12838348</ref><ref name ='Wang'>PMID:17485386</ref> `
 == Z-DNA binding proteins ==