Sandbox Z-DNA: Difference between revisions
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DLM-1 is also known as Z-DNA binding protein 1 (ZBP1). DLM-1 is a tumor associated gene expressed in lymphatic tissues and is upregulated in the peritoneal lining of mice with mouse ovarian ascites tumor. DLM-1 has two Z-DNA binding domains analogous to the Z-alpha and Z- beta domains in ADAR1. Comparison of Z-DNA binding of DLM-1 and ADAR1 revealed a common structure recognition core within the binding domain. However the role of DLM-1 binding to Z-DNA in tumor development is not known. | DLM-1 is also known as Z-DNA binding protein 1 (ZBP1). DLM-1 is a tumor associated gene expressed in lymphatic tissues and is upregulated in the peritoneal lining of mice with mouse ovarian ascites tumor. DLM-1 has two Z-DNA binding domains analogous to the Z-alpha and Z- beta domains in ADAR1. Comparison of Z-DNA binding of DLM-1 and ADAR1 revealed a common structure recognition core within the binding domain. However the role of DLM-1 binding to Z-DNA in tumor development is not known. | ||
Z-DNA binding proteins have common structural characteristics. Z-DNA binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref> | Z-DNA binding proteins have common structural characteristics. Z-DNA binding domains of these proteins can substitute one another and thus can act as competitive inhibitors against one another. As explained above disruption in the Z-DNA binding region of E3L reduces its pathogenicity. All these observations are important pointers towards the biological importance of Z-DNA.<ref name ='Wang'>PMID:17485386</ref> | ||
== Movie Depicting ADAR1 binding to Z-DNA == | == Movie Depicting ADAR1 binding to Z-DNA == | ||