Sandbox Z-DNA: Difference between revisions
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<applet load='Z-dna.pdb' size='330' frame='true' align='right' caption='Z-DNA' scene ='Sandbox_Z-DNA/Structure_of_z-dna/3' /> | <applet load='Z-dna.pdb' size='330' frame='true' align='right' caption='Z-DNA' scene ='Sandbox_Z-DNA/Structure_of_z-dna/3' /> | ||
Z-DNA is a structural form of DNA which has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/1'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in anti-conformation and syn conformation. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> Z-DNA is thought play a role in regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | Z-DNA <scene name='Sandbox_Z-DNA/Default/1'> (default scene) </scene> is a structural form of DNA which has a different structure from the more common <scene name='Sandbox_Z-DNA/Bdna/1'>B-DNA</scene> form.It is a left-handed double helix wherein the sugar-phosphate backbone has a zigzag pattern due to the alternate stacking of bases in anti-conformation and syn conformation. In Z-DNA only a minor groove is present and the major groove is absent. The residues that allow sequence-specific recognition of Z-DNA are present on the convex outer surface.<ref name = 'Rich'> PMID:12838348</ref> Z-DNA is thought play a role in regulation of gene expression, DNA processing events and/or genetic instability.<ref name = 'Wang'>PMID:17485386</ref> | ||
== Structure == | == Structure == | ||