Sandbox Z-DNA: Difference between revisions
No edit summary |
No edit summary |
||
| Line 13: | Line 13: | ||
=== Vaccinia virus E3L protein === | === Vaccinia virus E3L protein === | ||
E3L protein of vaccinia virus acts as an immune modulator and is required for replication of the virus. The N-terminal region of E3L is similar to the Z-alpha domain of ADAR1 but has a lower binding affinity to Z-DNA than ADAR1 or DLM-1. Though the C-terminal of E3L is sufficient for viral replication it is the N-terminal which is responsible for pathogenicity. Mutations or deletions in the N-terminal region reduces the pathogenicity of the virus. Replacement of this domain with its corresponding analogues from ADAR1 or DLM-1 generates a chimeric virus which is as lethal as the wild type virus. Thus a drug which can block the binding of E3L to Z-DNA may be an effective therapy in preventing pathogenicity. Similarity of E3L to variola also suggests that such drugs might be effective against small pox. | E3L protein of vaccinia virus acts as an immune modulator and is required for replication of the virus. The <scene name='Sandbox_Z-DNA/E3lzalpha/2'> N-terminal</scene> region of E3L is similar to the Z-alpha domain of ADAR1 but has a lower binding affinity to Z-DNA than ADAR1 or DLM-1. Though the C-terminal of E3L is sufficient for viral replication it is the N-terminal which is responsible for pathogenicity. Mutations or deletions in the N-terminal region reduces the pathogenicity of the virus. Replacement of this domain with its corresponding analogues from ADAR1 or DLM-1 generates a chimeric virus which is as lethal as the wild type virus. Thus a drug which can block the binding of E3L to Z-DNA may be an effective therapy in preventing pathogenicity. Similarity of E3L to variola also suggests that such drugs might be effective against small pox. | ||
=== DLM-1 === | === DLM-1 === | ||