1eo1: Difference between revisions

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'''Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum'''<br />
'''Solution structure of hypothetical protein MTH1175 from Methanobacterium thermoautotrophicum'''<br />


==Overview==
==Overview==
The solution structure of MTH1175, a 124-residue protein from the archaeon, Methanobacterium thermoautotrophicum has been determined by NMR, spectroscopy. MTH1175 is part of a family of conserved hypothetical, proteins (COG1433) with unknown functions which contains multiple paralogs, from all complete archaeal genomes and the archaeal gene-rich bacterium, Thermotoga maritima. Sequence similarity indicates this protein family may, be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts, an alpha/beta topology with a single mixed beta-sheet, and contains two, flexible loops and an unstructured C-terminal tail. The fold resembles, that of Ribonuclease H and similar proteins, but differs from these in, several respects, and is not likely to have a nuclease activity.
The solution structure of MTH1175, a 124-residue protein from the archaeon Methanobacterium thermoautotrophicum has been determined by NMR spectroscopy. MTH1175 is part of a family of conserved hypothetical proteins (COG1433) with unknown functions which contains multiple paralogs from all complete archaeal genomes and the archaeal gene-rich bacterium Thermotoga maritima. Sequence similarity indicates this protein family may be related to the nitrogen fixation proteins NifB and NifX. MTH1175 adopts an alpha/beta topology with a single mixed beta-sheet, and contains two flexible loops and an unstructured C-terminal tail. The fold resembles that of Ribonuclease H and similar proteins, but differs from these in several respects, and is not likely to have a nuclease activity.


==About this Structure==
==About this Structure==
1EO1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1EO1 OCA].  
1EO1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EO1 OCA].  


==Reference==
==Reference==
Line 13: Line 13:
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Cort, J.R.]]
[[Category: Cort, J R.]]
[[Category: Kennedy, M.A.]]
[[Category: Kennedy, M A.]]
[[Category: NESG, Northeast.Structural.Genomics.Consortium.]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: mixed a/b protein]]
[[Category: mixed a/b protein]]
[[Category: mixed beta sheet]]
[[Category: mixed beta sheet]]
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[[Category: structural genomics]]
[[Category: structural genomics]]


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