Nitric Oxide Synthase: Difference between revisions

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Michael Skovbo Windahl, Sara Toftegaard Petersen, Mathilde Thomsen, Mette Trauelsen, Eran Hodis, Jaime Prilusky, Karl Oberholser, Alexander Berchansky, Michal Harel, Ann Taylor

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 Nitric Oxide Synthase (NOS) is an enzyme catalysing the formation of L-Citrulline and Nitric Oxide[http://en.wikipedia.org/wiki/Nitric_Oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kD subunits.
-In mammals three isozymes of NOS has been identified: Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS)<ref>Flemming, I., Chapter 3, Biology of Nitric Oxide Synthases, from Microcirculation, Editors Ronald F. Tuma, R. F., Durán, W. N., and Ley, K., 2nd edition, Academic Press, 2008</ref>. (~The NOS enzymes are found in numeral organisms. Most facts used here are from the human NOS, but sites from different organisms are used.~). Neuronal NOS is producing NO in the nervous tissue in both the peripheral and the central nervous system. nNOS is functioning in cell signaling and communication - a vital part of the nervous tissue. Inducible NOS is connected with the immune system or in general...(!?). Endothelial NOS is controlling the amount of NO signaling in the endothelial cells eg. blood vessel dilation.  An overview the structural organization of the NOS homodimer is given below. All cofactors are included and the electron transfer pathway which takes place in NOS is indicated.
+In mammals three isozymes of NOS has been identified: Neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS)<ref>Flemming, I., Chapter 3, Biology of Nitric Oxide Synthases, from Microcirculation, Editors Ronald F. Tuma, R. F., Durán, W. N., and Ley, K., 2nd edition, Academic Press, 2008</ref>. (~The NOS enzymes are found in numeral organisms. Most facts used here are from the human NOS, but sites from different organisms are used.~). Neuronal NOS is producing NO in the nervous tissue in both the peripheral and the central nervous system. nNOS is functioning in cell signaling and communication - a vital part of the nervous tissue. Inducible NOS is connected with the immune system or induced systems in the organism. Endothelial NOS is controlling the amount of NO signaling in the endothelial cells eg. blood vessel dilation.  An overview the structural organization of the NOS homodimer is given below. All cofactors are included and the electron transfer pathway which takes place in NOS is indicated.
 [[Image:NOS_OVERSIGT.JPG|400 px|right]]