1u9b: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1U9B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Active as [[http://en.wikipedia.org/wiki/ | 1U9B is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]]. Active as [[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]]. Structure known Active Site: C93. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1U9B OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ubiquitin--protein ligase]] | |||
[[Category: Bernards, R.]] | [[Category: Bernards, R.]] | ||
[[Category: Hateboer, G.]] | [[Category: Hateboer, G.]] | ||
| Line 24: | Line 25: | ||
[[Category: ubiquitin-directed proteolysis]] | [[Category: ubiquitin-directed proteolysis]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:02:58 2007'' | ||
Revision as of 10:58, 30 October 2007
|
MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
OverviewOverview
Murine/human ubiquitin-conjugating enzyme Ubc9 is a functional homolog of, Saccharomyces cerevisiae Ubc9 that is essential for the viability of yeast, cells with a specific role in the G2-M transition of the cell cycle. The, structure of recombinant mammalian Ubc9 has been determined from two, crystal forms at 2.0 A resolution. Like Arabidopsis thaliana Ubc1 and S., cerevisiae Ubc4, murine/human Ubc9 was crystallized as a monomer, suggesting that previously reported hetero- and homo-interactions among, Ubcs may be relatively weak or indirect. Compared with the known crystal, structures of Ubc1 and Ubc4, which regulate different cellular processes, Ubc9 has a 5-residue insertion that forms a very exposed tight, beta-hairpin and a 2-residue insertion that forms a bulge in a loop close, to ... [(full description)]
About this StructureAbout this Structure
1U9B is a [Single protein] structure of sequence from [Mus musculus]. Active as [Ubiquitin--protein ligase], with EC number [6.3.2.19]. Structure known Active Site: C93. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system., Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK, J Biol Chem. 1997 Aug 22;272(34):21381-7. PMID:9261152
Page seeded by OCA on Tue Oct 30 10:02:58 2007