Sandbox 72

Please do NOT make changes to this Sandbox until after April 30, 2009. Sandboxes 60-80 are reserved until then for use by students of East High, Buffalo NY. FIBRINFIBRIN This protein works in the blood to quickly blocks any damage to the circulatory system, creating a temporary patch that allows time for more permanent repairs. It is a strong protein that is inactive until activated when a cut or lacerition to the skin is present. Fibrin is involved in the following biological processes of humans: Signal transduction, Blood coagulation, Platelet activation, and Protein polymerization .Fibrin is made from fibrinogen, a soluble plasma glycoprotein that is made by the liver. Processes in the coagulation cascade activate the protein : zymogen prothrombin to the serine protease thrombin, which is responsible for converting fibrinogen into fibrin. Fibrin is then cross linked by factor XIII to form a clot. FUNCTION & STRUCTUREFUNCTION & STRUCTURE Fibrin in the blood works along with two other molecules. These molecules are platelets (small fragments of blood cells that circulate in the blood), and neighboring blood vessels which constrict when needed. These methods work together along with Fibrin to create scabs which stop the flow of blood. The structure of Fibrin is mainly consists of single alpha helices shown in pink and beta sheets shown in yellow. The of The Fibrin Protein allows it to be flexible and clog lacerations to the skin. Apart of Fibrin, there is a vertebrate hexamer containing two sets of three different chains (α, β, and γ), linked to each other by bonds. Fibrin is more of a crystal structure with two double-d fragment from human fibrin with two bound ligands. The chemical structures of the ligands are Ca+2 ion, alpha-D-mannose (C6H1206), and D-glcosamine (C8H15NO6). spinqualitylabelsall models PDB ID 1m1j Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image 1m1j, resolution 2.70Å () Ligands: , , Related: 1ei3, 1fzc Structural annotation: Resources: CATH : 1M1Ja00, 1M1Jb02, 1M1Jb01, 1M1Jb03, 1M1Jc01, 1M1Jc02, 1M1Jc03, 1M1Jd00, 1M1Je01, 1M1Je03, 1M1Je02, 1M1Jf01, 1M1Jf02, 1M1Jf03 InterPro : Ipr012290, Ipr014716, Ipr014814, Ipr002181, Ipr014715 Pfam : PF08702, PF00147 SCOP : d1m1ja_, d1m1jf1, d1m1jf2 UniProt : P14448, Q02020, O93568 Functional annotation: Cellular component: fibrinogen complex Biological process: signal transduction blood coagulation platelet activation protein polymerization Molecular function: protein binding, bridging receptor binding Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB Resources: FirstGlance, OCA, PDBsum, RCSB Coordinates: save as pdb, mmCIF, xml