2v5m: Difference between revisions
New page: left|200px<br /> <applet load="2v5m" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v5m, resolution 1.95Å" /> '''STRUCTURAL BASIS FO... |
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==About this Structure== | ==About this Structure== | ||
2V5M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]]. | 2V5M is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]] with GOL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: neurobiology spl]] | [[Category: neurobiology spl]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:50:44 2007'' | ||
Revision as of 18:46, 30 October 2007
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STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY
OverviewOverview
The Dscam gene gives rise to thousands of diverse cell surface receptors, thought to provide homophilic and heterophilic recognition specificity for, neuronal wiring and immune responses. Mutually exclusive splicing allows, for the generation of sequence variability in three immunoglobulin, ecto-domains, D2, D3 and D7. We report X-ray structures of the, amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam, isoforms. The structures reveal a horseshoe configuration, with variable, residues of D2 and D3 constituting two independent surface epitopes on, either side of the receptor. Both isoforms engage in homo-dimerization, coupling variable domain D2 with D2, and D3 with D3. These interactions, involve symmetric, antiparallel pairing of identical peptide segments from, ... [(full description)]
About this StructureAbout this Structure
2V5M is a [Single protein] structure of sequence from [Drosophila melanogaster] with GOL as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structural basis of Dscam isoform specificity., Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D, Nature. 2007 Aug 26;. PMID:17721508
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