Sandbox10: Difference between revisions
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Myosin II is found in the myofibers of skeletal, smooth, and cardiac muscle tissue where the protein forms the thick filaments. The myosin of the thick filaments has the ability to bind the thin filaments, composed of actin. The myosin head then rotates and pulls the two filaments past one another providing the basis for muscle contraction. | Myosin II is found in the myofibers of skeletal, smooth, and cardiac muscle tissue where the protein forms the thick filaments. The myosin of the thick filaments has the ability to bind the thin filaments, composed of actin. The myosin head then rotates and pulls the two filaments past one another providing the basis for muscle contraction. | ||
{{STRUCTURE_2jhr | PDB=2jhr | SCENE= }} | {{STRUCTURE_2jhr | PDB=2jhr | SCENE= }} | ||
The portion of the protein that is shown is the motor domain of the heavy chain. This protein is largely composed of <scene name='Sandbox10/Helix/1'>alpha-helices</scene> connected by randomly oriented chains. There are also several areas of <scene name='Sandbox10/Betasheets/1'>beta-sheets</scene>, both parallel and anti-parallel. This component of the protein represents only one part of the hexamer the makes up the entire mosin unit. In addition there is another heavy chain and four light chains. The tails of the two heavy chains, which can not be seen, coil about one another to form the thick filament. The four lights chains bind the myosin between the head and tail region, two light chain molecules per heavy chain. These light chains are known as the essential light chain and the regulatory light chain. | The portion of the protein that is shown is the motor domain of the heavy chain. This protein is largely composed of <scene name='Sandbox10/Helix/1'>alpha-helices</scene> connected by randomly oriented chains. There are also several areas of <scene name='Sandbox10/Betasheets/1'>beta-sheets</scene>, both parallel and anti-parallel. This component of the protein represents only one part of the hexamer the makes up the entire mosin unit. In addition there is another heavy chain and four light chains. The tails of the two heavy chains, which can not be seen, coil about one another to form the thick filament. The four lights chains bind the myosin between the head and tail region, two light chain molecules per heavy chain. These light chains are known as the essential light chain and the regulatory light chain. | ||