3g0f: Difference between revisions
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Revision as of 10:20, 3 June 2009
KIT kinase domain mutant D816H in complex with sunitinibKIT kinase domain mutant D816H in complex with sunitinib
Template:ABSTRACT PUBMED 19164557
DiseaseDisease
Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[164920], Germ cell tumors OMIM:[164920], Leukemia, acute myeloid OMIM:[164920], Mast cell leukemia OMIM:[164920], Mastocytosis with associated hematologic disorder OMIM:[164920], Piebaldism OMIM:[164920]
About this StructureAbout this Structure
3G0F is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gajiwala KS, Wu JC, Christensen J, Deshmukh GD, Diehl W, Dinitto JP, English JM, Greig MJ, He YA, Jacques SL, Lunney EA, McTigue M, Molina D, Quenzer T, Wells PA, Yu X, Zhang Y, Zou A, Emmett MR, Marshall AG, Zhang HM, Demetri GD. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1542-7. Epub 2009 Jan 21. PMID:19164557
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Demetri, G D.
- Gajiwala, K S.
- Lunney, E A.
- Wu, J C.
- Atp-binding
- Disease mutation
- Drug resistance
- Glycoprotein
- Immunoglobulin domain
- Kinase
- Kit kinase domain
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Receptor
- Sutent binding
- Transferase
- Transmembrane
- Tyrosine-protein kinase