Sandbox Eric Martz: Difference between revisions
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The <b>morph</b> | The <b>morph</b> | ||
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from a Cullin-RING ligase <b>dimer</b> ([[3dpl]]) to the <b>trimer</b> resulting from NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to Lys724 of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by the RING N-terminus which remains embedded in Cullin. ''The contraction and re-expansion of the C-terminal domain during rotation is an artifact of the morphing algorithm.'' | from a Cullin-RING ligase <b>dimer</b> ([[3dpl]]) to the <b>trimer</b> resulting from NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to Lys724 of Cullin; [[3dqv]]). NEDD8 binds and rotates the C-terminal domain of Cullin, releasing the folded RING domain from its Cullin-binding site. RING remains attached to Cullin by the RING N-terminus which remains embedded in Cullin. ''The contraction and re-expansion of the C-terminal domain during rotation is an artifact of the morphing algorithm.'' | ||
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==Notes and References== | ==Notes and References== | ||
<references /> | <references /> | ||