2idy: Difference between revisions
New page: left|200px<br /><applet load="2idy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2idy" /> '''NMR Structure of the SARS-CoV non-structural... |
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[[Image:2idy.gif|left|200px]]<br /><applet load="2idy" size=" | [[Image:2idy.gif|left|200px]]<br /><applet load="2idy" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''NMR Structure of the SARS-CoV non-structural protein nsp3a'''<br /> | '''NMR Structure of the SARS-CoV non-structural protein nsp3a'''<br /> | ||
==Overview== | |||
This paper describes the structure determination of nsp3a, the N-terminal, domain of the severe acute respiratory syndrome coronavirus (SARS-CoV), nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of, residues 1 to 112 and a flexibly extended glutamic acid-rich domain of, residues 113 to 183. In addition to the four beta-strands and two, alpha-helices that are common to ubiquitin-like folds, the globular domain, of nsp3a contains two short helices representing a feature that has not, previously been observed in these proteins. Nuclear magnetic resonance, chemical shift perturbations showed that these unique structural elements, are involved in interactions with single-stranded RNA. Structural, similarities with proteins involved in various cell-signaling pathways, indicate possible roles of nsp3a in viral infection and persistence. | |||
==About this Structure== | ==About this Structure== | ||
2IDY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ | 2IDY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDY OCA]. | ||
[[Category: | |||
==Reference== | |||
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus., Serrano P, Johnson MA, Almeida MS, Horst R, Herrmann T, Joseph JS, Neuman BW, Subramanian V, Saikatendu KS, Buchmeier MJ, Stevens RC, Kuhn P, Wuthrich K, J Virol. 2007 Nov;81(21):12049-60. Epub 2007 Aug 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17728234 17728234] | |||
[[Category: Sars coronavirus]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Almeida, M.S.]] | [[Category: Almeida, M.S.]] | ||
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[[Category: sars coronavirus nmr nsp3a]] | [[Category: sars coronavirus nmr nsp3a]] | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
[[Category: viral protein]] | |||
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